Tsaregorodtseva, Tatiana S.; Radyukhina, Maria A.; Ayupova, Aisylu I.; Solovyeva, Valeriya V.; Sufianov, Albert A.; Sufianova, Galina Z.; Rizvanov, Albert A. (2026) Safety of Adeno-Associated Viral Vectors in Gene Therapy: Mechanisms of Toxicity, Clinical Risks, and Strategies for Their Minimization. International Journal of Molecular Sciences, 27 (11). doi:10.3390/ijms27114818

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	Isildak (2018) Case Rep. Ophthalmol. Med. Therapeutic Effect of Anti-VEGF for Age-Related Macular Degeneration in the Untreated Fellow Eye 2018, 8561895
	Moffit (2025) Mol. Ther. Methods Clin. Dev. Nonclinical Strategies and Considerations to Enable the Redosing of Gene Therapies 33, 101520
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	Not Yet Imported: Gene Therapy - journal-article : 10.1038/gt.2017.75 If you would like this item imported into the Digital Library, please contact us quoting Journal ID
	Bertin, Berangere, Veron, Philippe, Leborgne, Christian, Deschamps, Jack-Yves, Moullec, Sophie, Fromes, Yves, Collaud, Fanny, Boutin, Sylvie, Latournerie, Virginie, van Wittenberghe, Laetitia, Delache, Benoit, Le Grand, Roger, Dereuddre-Bosquet, Nathalie, Benveniste, Olivier, Moullier, Philippe, Masurier, Carole, Merten, Otto, Mingozzi, Federico (2020) Capsid-specific removal of circulating antibodies to adeno-associated virus vectors. Scientific Reports, 10. doi:10.1038/s41598-020-57893-z
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	Cao (2025) Gene Ther. Safety, Efficacy, and Immunogenicity of a Novel IgG Degrading Enzyme (KJ103): Results from Two Randomised, Blinded, Phase 1 Clinical Trials 32, 223
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	Ye, X. (1999) Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer. Science, 283 (5398). 88-91 doi:10.1126/science.283.5398.88
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	(2026, March 26). These Highlights Do Not Include All the Information Needed to Use ZOLGENSMA Safely and Effectively. See Full Prescribing Information for ZOLGENSMA. ZOLGENSMA® (Onasemnogene Abeparvovec-Xioi) Suspension, for Intravenous Infusion. Initial U.S. Approval: 2019, Available online: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=68cd4f06-70e1-40d8-bedb-609ec0afa471.
	(2026, March 26). These Highlights Do Not Include All the Information Needed to Use LUXTURNA Safely and Effectively. See Full Prescribing Information for LUXTURNA.LUXTURNA (Voretigene Neparvovec-Rzyl) Intraocular Suspension for Subretinal Injection. Initial U.S. Approval: 2017, Available online: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=08313a24-e7ce-457a-bb3f-161bc45517ee.
	(2026, March 26). These Highlights Do Not Include All the Information Needed to Use HEMGENIX Safely and Effectively. See Full Prescribing Information for HEMGENIX. HEMGENIX (Etranacogene Dezaparvovec-Drlb) Suspension, for Intravenous Infusion. Initial U.S. Approval: 2022, Available online: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=35b2db65-4c6c-4173-ab56-b2bca69193bd&type=display.
	(2026, March 26). These Highlights Do Not Include All the Information Needed to Use ROCTAVIAN Safely and Effectively. See Full Prescribing Information for ROCTAVIAN. ROCTAVIAN (Valoctocogene Roxaparvovec-Rvox) Suspension for Intravenous Infusion. Initial U.S. Approval: 2023, Available online: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=0dcf7185-8e1c-456a-9d4e-7cc316400118.
	(2026, March 26). These Highlights Do Not Include All the Information Needed to Use ELEVIDYS® Safely and Effectively. See Full Prescribing Information for ELEVIDYS. ELEVIDYS (Delandistrogene Moxeparvovec-Rokl) Suspension, for Intravenous Infusion. Initial U.S. Approval: 2023, Available online: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=3525abcd-fbd2-46c5-9706-cffdf2e8a361&type=display.
	(2026, March 26). These Highlights Do Not Include All the Information Needed to Use KEBILIDI Safely and Effectively. See Full Prescribing Information for KEBILIDI. KEBILIDI (Eladocagene Exuparvovec-Tneq) Suspension, for Intraputaminal Infusion. Initial U.S. Approval: 2024, Available online: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=9d6a6401-c6b5-4f29-af11-67707d249482&type=display.
	European Medicines Agency (EMA) (2026, March 26). Upstaza. Available online: https://www.ema.europa.eu/en/medicines/human/EPAR/upstaza.
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	Mok (2024) Proc. Natl. Acad. Sci. USA Post-Immunotherapy CTLA-4 Ig Treatment Improves Antitumor Efficacy 121, e2404661121
	Not Yet Imported: - journal-article : 10.1111/jth.14757 If you would like this item imported into the Digital Library, please contact us quoting Journal ID
	Meliani, Amine, Boisgerault, Florence, Hardet, Romain, Marmier, Solenne, Collaud, Fanny, Ronzitti, Giuseppe, Leborgne, Christian, Costa Verdera, Helena, Simon Sola, Marcelo, Charles, Severine, Vignaud, Alban, van Wittenberghe, Laetitia, Manni, Giorgia, Christophe, Olivier, Fallarino, Francesca, Roy, Christopher, Michaud, Alicia, Ilyinskii, Petr, Kishimoto, Takashi Kei, Mingozzi, Federico (2018) Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration. Nature Communications, 9. doi:10.1038/s41467-018-06621-3
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	Fuchs, Sebastian P.; Mondragon, Paula G.; Zabizhin, Rachel; Tomer, Shallu; Wang, Li; Cook, Ethan; Dudley, Dawn M.; Weisgrau, Kimberly L.; Furlott, Jessica; Coonen, Jennifer; et al. (2025) Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies. Nature Communications, 16 (1). doi:10.1038/s41467-025-63970-6
	Ilyinskii, Petr O., Michaud, Alicia M., Roy, Christopher J., Rizzo, Gina L., Elkins, Stephanie L., Capela, Teresa, Chowdhury, Aparajita C., Leung, Sheldon S., Kishimoto, Takashi K. (2021) Enhancement of liver-directed transgene expression at initial and repeat doses of AAV vectors admixed with ImmTOR nanoparticles. Science Advances, 7 (9). doi:10.1126/sciadv.abd0321
	Not Yet Imported: - journal-article : 10.1089/hum.2023.194 If you would like this item imported into the Digital Library, please contact us quoting Journal ID
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	Smith (2024) Mol. Ther. Engineered IgM and IgG Cleaving Enzymes for Mitigating Antibody Neutralization and Complement Activation in AAV Gene Transfer 32, 2080
	Not Yet Imported: - journal-article : 10.1016/j.ymthe.2005.03.018 If you would like this item imported into the Digital Library, please contact us quoting Journal ID
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	Not Yet Imported: - journal-article : 10.3389/fimmu.2020.00494 If you would like this item imported into the Digital Library, please contact us quoting Journal ID
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	Not Yet Imported: Molecular Therapy - journal-article : 10.1038/mt.2011.108 If you would like this item imported into the Digital Library, please contact us quoting Journal ID
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	Cheng (2025) Mol. Ther. Methods Clin. Dev. Probing Aspects of Extracellular Vesicle Associated AAV Allows Increased Vector Yield and Insight into Its Transduction and Immune-Evasive Properties 33, 101407
	Not Yet Imported: Blood Advances - journal-article : 10.1182/bloodadvances.2017010181 If you would like this item imported into the Digital Library, please contact us quoting Journal ID
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	Wang (2024) Interdiscip. Med. Adeno-associated Virus Vectors for Gene Therapy—Focusing on Melanoma 2, e20240031

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