Su Pwint, Nang Thee; Li, Chunning; Gao, Tong; Wang, Yuze; Fujisawa, Masayoshi; Ohara, Toshiaki; Sakaguchi, Masakiyo; Yoshimura, Teizo; Matsukawa, Akihiro (2025) Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells. International Journal of Molecular Sciences, 26 (20). doi:10.3390/ijms262010072
| Reference Type | Journal (article/letter/editorial) | ||
|---|---|---|---|
| Title | Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells | ||
| Journal | International Journal of Molecular Sciences | ||
| Authors | Su Pwint, Nang Thee | Author | |
| Li, Chunning | Author | ||
| Gao, Tong | Author | ||
| Wang, Yuze | Author | ||
| Fujisawa, Masayoshi | Author | ||
| Ohara, Toshiaki | Author | ||
| Sakaguchi, Masakiyo | Author | ||
| Yoshimura, Teizo | Author | ||
| Matsukawa, Akihiro | Author | ||
| Year | 2025 (October 16) | Volume | 26 |
| Issue | 20 | ||
| Publisher | MDPI AG | ||
| DOI | doi:10.3390/ijms262010072Search in ResearchGate | ||
| Generate Citation Formats | |||
| Mindat Ref. ID | 19086680 | Long-form Identifier | mindat:1:5:19086680:0 |
| GUID | 0 | ||
| Full Reference | Su Pwint, Nang Thee; Li, Chunning; Gao, Tong; Wang, Yuze; Fujisawa, Masayoshi; Ohara, Toshiaki; Sakaguchi, Masakiyo; Yoshimura, Teizo; Matsukawa, Akihiro (2025) Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells. International Journal of Molecular Sciences, 26 (20). doi:10.3390/ijms262010072 | ||
| Plain Text | Su Pwint, Nang Thee; Li, Chunning; Gao, Tong; Wang, Yuze; Fujisawa, Masayoshi; Ohara, Toshiaki; Sakaguchi, Masakiyo; Yoshimura, Teizo; Matsukawa, Akihiro (2025) Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells. International Journal of Molecular Sciences, 26 (20). doi:10.3390/ijms262010072 | ||
| In | (2025, October) International Journal of Molecular Sciences Vol. 26 (20). MDPI AG | ||
References Listed
These are the references the publisher has listed as being connected to the article. Please check the article itself for the full list of references which may differ. Not all references are currently linkable within the Digital Library.
| Bray (2024) CA Cancer J. Clin. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries 74, 229 | |
| Siegel (2025) CA Cancer J. Clin. Cancer statistics, 2025 75, 10 | |
| Not Yet Imported: - journal-article : 10.1038/s41523-022-00468-0 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.3390/cancers15041217 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: Cancers - journal-article : 10.3390/cancers11050707 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1038/bjc.2016.403 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1158/1078-0432.CCR-18-4044 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: Molecular Metabolism - journal-article : 10.1016/j.molmet.2024.101876 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: Human Genomics - journal-article : 10.1186/s40246-017-0109-3 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Safonov (2025) Nat. Commun. A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations 16, 3121 | |
| Not Yet Imported: - journal-article : 10.1038/s42003-023-04815-0 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.3390/cells9112365 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1038/s41388-021-02156-y If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: Cellular Signalling - journal-article : 10.1016/j.cellsig.2022.110487 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
 | |
| Dunzendorfer-Matt, Theresia, Mercado, Ellen L., Maly, Karl, McCormick, Frank, Scheffzek, Klaus (2016) The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Proceedings of the National Academy of Sciences, 113 (27) 7497-7502 doi:10.1073/pnas.1607298113 |
| Not Yet Imported: - journal-article : 10.1016/j.celrep.2020.107909 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1038/bjc.2012.507 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Wang (2020) Oncol. Rep. Spred2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by impairing ERK signaling 44, 174 | |
| Not Yet Imported: - posted-content : 10.1101/2021.07.23.453537 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Gao, Tong, Yang, Xu, Fujisawa, Masayoshi, Ohara, Toshiaki, Wang, Tianyi, Tomonobu, Nahoko, Sakaguchi, Masakiyo, Yoshimura, Teizo, Matsukawa, Akihiro (2023) SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells. International Journal of Molecular Sciences, 24 (5) 4996 doi:10.3390/ijms24054996 |
| Ota (2025) Pathol. Res. Pract. Expression of SPRED2 in the lung adenocarcinoma 265, 155721 | |
| Not Yet Imported: - journal-article : 10.3390/cancers14040954 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Wang, Tianyi, Gao, Tong, Fujisawa, Masayoshi, Ohara, Toshiaki, Sakaguchi, Masakiyo, Yoshimura, Teizo, Matsukawa, Akihiro (2024) SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes. International Journal of Molecular Sciences, 25 (11) 6269 doi:10.3390/ijms25116269 |
| Not Yet Imported: Genes & Development - journal-article : 10.1101/gad.341222.120 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1016/j.cell.2019.12.023 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1016/j.jbc.2023.104789 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Hirata, Y., Brems, H., Van der Auweraer, S., Ohyagi, M., Iizuka, M., Mise-Omata, S., Ito, M., Messiaen, L., Mizuno, S., and Takahashi, S. (2024). Legius syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration. J. Biol. Chem., 300. | |
| Not Yet Imported: - journal-article : 10.1038/s41523-018-0080-8 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1038/s41420-021-00747-y If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Qiao (2019) Int. J. Clin. Exp. Pathol. Neurofibromin 1 expression is negatively correlated with malignancy and prognosis of epithelial ovarian cancer 12, 1702 | |
| Not Yet Imported: - journal-article : 10.1038/s41388-021-02074-z If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1042/BSR20110060 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1038/modpathol.2017.105 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Führer, Sebastian, Tollinger, Martin, Dunzendorfer-Matt, Theresia (2019) Pathogenic Mutations Associated with Legius Syndrome Modify the Spred1 Surface and Are Involved in Direct Binding to the Ras Inactivator Neurofibromin. Journal of Molecular Biology, 431 (19). 3889-3899 doi:10.1016/j.jmb.2019.07.038 |
| Not Yet Imported: Oncotarget - journal-article : 10.18632/oncotarget.8357 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1042/BJ20041284 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: Journal of Cell Biology - journal-article : 10.1083/jcb.200905118 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1038/s41571-021-00565-2 If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1038/s41392-023-01705-z If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Not Yet Imported: - journal-article : 10.1186/s12935-022-02666-z If you would like this item imported into the Digital Library, please contact us quoting Journal ID | |
| Sabit, H., Rashwan, S., Albrahim, Y., Wadan, A.S., Radwan, F., Alqosaibi, A.I., Abdel-Ghany, S., and Arneth, B. (2025). Targeting Resistance Pathways in Breast Cancer Through Precision Oncology: Nanotechnology and Immune Modulation Approaches. Biomedicines, 13. |
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